DOCUMENT

SPRING 2026 InTouch | 19 What is this trial about? This clinical trial is for individuals like you with DMD. The trial is being done to learn more about an investigational drug called KER- 065 (rinvatercept). The trial will test whether KER-065 is safe for individuals with DMD who are 9 years old and older. It will also test how the drug affects your muscles and bones. Why should I join the trial? Being in this clinical trial may or may not help your DMD. However, we believe some benefits might include: • Supporting research for individuals with DMD • Close monitoring of your health by a professional research team • A chance to contribute to what we know about DMD and potentially help other individuals with DMD in the future How long is this trial? The trial is about 14 months long and requires around 21 visits to the research site. What is involved in the trial? First, if you agree to join the trial, you will have several medical tests RESEARCH NEWS Potential new treatment for individuals with Duchenne Muscular Dystrophy (DMD) Take part in a clinical trial testing a novel investigational drug for DMD. done to see if the trial is right for you. This period may take up to 6 weeks. If you are eligible for the trial, you will start coming to the research site every four weeks for trial treatment with the investigational drug. This is given by a small injection just under the skin. In some cases, certain visits may be done at home between trial treatments at the research site. You will need to wear an activity monitor for four 2-to-4-week periods during the trial. The monitor is a small wireless device with two sensors; one will wrap around your wrist, and the other will wrap around your ankle. You will wear these sensors when you are awake. A few times a year you will have imaging procedures performed to take a look at your heart, muscles, and bones. These procedures may require you to visit a different location than where you go for your regular clinic appointments. The procedures will require you to lie still but are generally painless. The details of each imaging procedure will be explained to you. Are there risks in the trial? There may be risks from taking the investigational drug. More information about the possible risks, side effects, and discomforts related to the trial is available in the informed consent and assent form you will be asked to read and sign. If you have any questions, these should be discussed with the trial doctor. Do I have to be in the trial? No. Being in a clinical trial is completely voluntary. You do not have to join the trial if you do not want to. Even if you join the trial, you can speak to your doctor and stop being in the trial at any time. How do I join the trial? If you want to be in the trial, the trial doctor will give you and your parent/ caregiver more information. The trial doctor will be happy to answer any questions that you have. To learn more go to: optimalclinicaltrials.com/open-trials Or call: 0800 73 73 27 extension 1. If you are eligible for the trial, you will start coming to the research site every four weeks for trial treatment with the investigational drug.