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16 | InTouch AUTUMN 2026 Further Resources CMT Research Foundation https://www.cmtrf.org Charcot-Marie-Tooth Association https://cmtausa.org The National Institute of Neurologic Disorders and Stroke https://www.ninds. nih.gov/health-information/disorders/ charcot-marie-tooth-disease WHAT IS CHARCOT-MARIE-TOOTH DISEASE? Continued from previous page. A balanced diet is recommended. No specific vitamin or supplement has been shown to treat CMT unless a true deficiency is present. Maintaining a healthy weight is important, as excess weight increases fatigue and strain on weakened muscles and joints. In children, both underweight and obesity have been associated with greater disability progression. can be helpful, but comfort and proper fit are essential. Regular follow up and adjustment improve long term use and satisfaction. Surgery Foot deformities such as high arches and hammertoes are common in CMT. When bracing and therapy are not sufficient, surgery may be considered to improve alignment and function. Surgical decisions are individualized and are typically made in collaboration with neurology, orthopaedics and rehabilitation specialists. Exercise and Rehabilitation Low to moderate intensity exercise is generally safe and encouraged for most individuals with CMT. Research shows that appropriately designed aerobic and strengthening programs are safe and can improve fitness and function without causing harm. Physical therapy may focus on: • Strengthening unaffected or mildly affected muscles • Stretching to maintain flexibility • Balance training to reduce falls • Energy conservation techniques. Regular activity also supports overall health and may reduce fatigue. Skin Care and Safety Because many people with CMT have reduced sensation in their hands and feet, it is important to take extra care to prevent injuries. Burns and skin injuries can occur without being felt right away. Hot cups and cooking items should be handled carefully. The temperature of bath water, heating pads, hot water bottles, and foot soaks should always be checked before touching the skin. Regular inspection of the feet for cuts, blisters or pressure areas is also recommended. Nutrition and Weight Management A balanced diet is recommended. No specific vitamin or supplement has been shown to treat CMT unless a true deficiency is present. Maintaining a healthy weight is important, as excess weight increases fatigue and strain on weakened muscles and joints. In children, both underweight and obesity have been associated with greater disability progression. Medications to Use with Caution Some medications may worsen peripheral neuropathy. Patients should review medication lists with their neuromuscular specialist. Up to date guidance is available through the MDANZ and patient advocacy organizations. Research into Charcot- Marie-Tooth Disease Research is ongoing to better understand the genetic and molecular causes of CMT and to develop targeted treatments. While there are currently no disease modifying therapies, several promising approaches are under investigation, including gene based therapies for certain subtypes. Clinical trials are underway internationally, particularly for CMT1A. Advances in genetic research continue to improve understanding of the condition and may lead to more targeted treatments in the future.