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Brain Talks The future of Motor Neuron Disease research Ammar Al-Chalabi is Head of the Department of Basic and Clinical Neuroscience at The Maurice Wohl Clinical Neuroscience Institute at King’s College London. He has numerous other roles too, including leading the multinational BRAIN-MEND consortium, which looks for overlaps and differences in neurodegenerative diseases. His research looks at genetic and environmental causes of MND, including the six steps that lead to the onset of MND. Professor Ammar Al-Chalabi King’s College, London 18 Headlines At the end of 2019, the Motor Neurone Disease (MND) Association of New Zealand hosted their inaugural research conference. They have been committed to developing a globally linked comprehensive national MND research programme for the last four years. They applied for a grant in the 2019B grant round from the Foundation and were awarded a conference and training course grant to fly two world-class MND researchers to New Zealand to present their research at the conference. This conference created a forum for knowledge exchange and the opportunity to build international alliances to connect New Zealanders to global research initiatives. Professor Ammar Al-Chalabi of King’s College in London and Professor Martin Turner of Oxford University are both MND researchers and are collaborating on a research project together. They both presented in December at the MND New Zealand conference and were interviewed on their joint projects. Q: What’s your focus for 2020? One of the new areas we're looking at is non-motor symptoms. These are symptoms that people don’t reveal to their doctor because consultations are always focussed on weakness. For example, you might have a frozen shoulder because you can't move your arm, or backache because your posture is awkward. Itching, swollen legs, cold limbs and urinary disturbances are other symptoms people don't tell us about. Fatigue is another big symptom. Tackling these symptoms can improve quality of life for people with MND. It’s a big opportunity. Q: What’s the value of international collaboration for MND research? Many things related to the brain can only be studied if you have large numbers. While MND has a lifetime risk of one in 300, i.e. it’s relatively common, it shortens life dramatically so finding people for studies is a challenge. By working with teams in other countries, we have access to thousands of people with MND. Part of international collaboration is attending conferences and explaining what you’re doing, so that others can see how their research could assist yours. Q: What’s the most exciting thing you’re working on at the moment? I’ve been working with Professor Martin Turner, because we are both interested in the different subtypes of MND. He does it from an imaging and biomarkers point of view, I do it from the genetics point of view. We’ve just written a paper about a very interesting idea. It’s to do with how all the nerve groups that are affected in MND are the same nerve groups that are paralysed during REM sleep. Likewise, all the nerve groups that are protected are the ones that aren’t paralysed. For example, in REM sleep your eyes move, and your eyes aren’t usually affected in MND until the very last stages. You’re obviously breathing during REM sleep, and that’s the last thing to be affected by MND. You don’t become incontinent in REM sleep, which also applies with MND. We even looked at hearing. Little muscles that are active in your ear during REM sleep are also resistant to MND. It all means that sleep research might feed into MND research.